2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141278
    Methyltetrazine-PEG4-maleimide 1802908-02-6
    Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-PEG4-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-PEG4-maleimide
  • HY-W096121
    PEG3 67439-82-1 98.00%
    PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG3
  • HY-W037355
    4-Maleimidobutyric acid 57078-98-5 99.86%
    4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    4-Maleimidobutyric acid
  • HY-126890
    Bis-PEG7-NHS ester 1334170-02-3 ≥98.0%
    Bis-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG7-NHS ester
  • HY-130151
    m-PEG7-CH2CH2COOH 1093647-41-6 99.39%
    m-PEG7-CH2CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG7-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG7-CH2CH2COOH
  • HY-40142
    1-N-Boc-3-hydroxyazetidine 141699-55-0 99.03%
    1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
    1-N-Boc-3-hydroxyazetidine
  • HY-135915
    Biotin-C5-NHS Ester 72040-63-2 ≥98.0%
    Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-C5-NHS Ester
  • HY-W007700
    8-Bromooctanoic acid 17696-11-6 99.89%
    8-Bromooctanoic acid is a PROTAC linker, and can be used for synthesis of PROTAC CYP1B1 degrader-2 (HY-158429).
    8-Bromooctanoic acid
  • HY-126958
    Biotin-PEG2-acid 1365655-89-5
    Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Biotin-PEG2-acid
  • HY-W072752
    endo-BCN-PEG2-NH2 1263166-93-3
    endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG2-NH2 contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG2-NH2
  • HY-140197
    Amino-PEG12-Boc 1383814-00-3 ≥98.0%
    Amino-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG12-Boc
  • HY-141367
    Bromo-PEG6-Boc 1393330-41-0
    Bromo-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG6-Boc
  • HY-W044155
    Azido-PEG2-azide 59559-06-7 98.11%
    Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-azide
  • HY-130486
    NH2-PEG6-Boc 1286281-32-0 ≥98.0%
    NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    NH2-PEG6-Boc
  • HY-W004701
    Br-C3-methyl ester 4897-84-1 98.61%
    Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).
    Br-C3-methyl ester
  • HY-W022232
    Boc-NH-PEG5-CH2CH2COOH 1347750-78-0
    Boc-NH-PEG5-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Boc-NH-PEG5-CH2CH2COOH
  • HY-140696
    m-PEG-OH (MW 2000) 9004-74-4
    m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-OH (MW 2000)
  • HY-W018174
    m-PEG3-Amine 74654-07-2 98.91%
    m-PEG3-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG3-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG3-Amine
  • HY-130342
    HO-PEG11-OH 6809-70-7
    HO-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG11-OH
  • HY-140677
    mPEG-amine (MW 5000) 80506-64-5 ≥98.0%
    mPEG-amine (mPEG-NH2) (MW 5000) is a modifier that can replace the sulfonic acid portion of the dye molecule to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes. mPEG-amine can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS to form a PEG coating on the surface of fluorescent microspheres for large-scale rotational cytoplasmic flow studies.
    mPEG-amine (MW 5000)
PROTAC Linkers Isoform Comparison

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